The Temple team also identified the mechanisms underlying the protective effects of extra-virgin olive oil. “We found that olive oil reduces brain inflammation but most importantly activates a process known as autophagy,” explained senior investigator Domenico Praticò, MD, Professor in the Departments of Pharmacology and Microbiology and the Center for Translational Medicine at LKSOM. Autophagy is the process by which cells break down and clear out intracellular debris and toxins, such as amyloid plaques and tau tangles.

“Brain cells from mice fed diets enriched with extra-virgin olive oil had higher levels of autophagy and reduced levels of amyloid plaques and phosphorylated tau,” Dr. Praticò said. The latter substance, phosphorylated tau, is responsible for neurofibrillary tangles, which are suspected of contributing to the nerve cell dysfunction in the brain that is responsible for Alzheimer's memory symptoms.

Previous studies have suggested that the widespread use of extra-virgin olive oil in the diets of people living in the Mediterranean areas is largely responsible for the many health benefits linked to the Mediterranean diet. “The thinking is that extra-virgin olive oil is better than fruits and vegetables alone, and as a monounsaturated vegetable fat it is healthier than saturated animal fats,” according to Dr. Praticò. (Photo Credit: Temple Health)

In order to investigate the relationship between extra-virgin olive oil and dementia, Dr. Praticò and colleagues used a well-established Alzheimer's disease mouse model. Known as a triple transgenic model, the animals develop three key characteristics of the disease: memory impairment, amyloid plagues, and neurofibrillary tangles.

The researchers divided the animals into two groups, one that received a chow diet enriched with extra-virgin olive oil and one that received the regular chow diet without it. The olive oil was introduced into the diet when the mice were six months old, before symptoms of Alzheimer's disease begin to emerge in the animal model.

In overall appearance, there was no difference between the two groups of animals. However, at age 9 months and 12 months, mice on the extra virgin olive oil-enriched diet performed significantly better on tests designed to evaluate working memory, spatial memory, and learning abilities.

Studies of brain tissue from both groups of mice revealed dramatic differences in nerve cell appearance and function. “One thing that stood out immediately was synaptic integrity,” Dr. Praticò said. The integrity of the connections between neurons, known as synapses, were preserved in animals on the extra-virgin olive oil diet. In addition, compared to mice on a regular diet, brain cells from animals in the olive oil group showed a dramatic increase in nerve cell autophagy activation, which was ultimately responsible for the reduction in levels of amyloid plaques and phosphorylated tau.

“This is an exciting finding for us,” explained Dr. Praticò. “Thanks to the autophagy activation, memory and synaptic integrity were preserved, and the pathological effects in animals otherwise destined to develop Alzheimer's disease were significantly reduced. This is a very important discovery, since we suspect that a reduction in autophagy marks the beginning of Alzheimer's disease.”

Dr. Praticò and colleagues plan next to investigate the effects of introducing extra-virgin olive oil into the diet of the same mice at 12 months of age, when they have already developed plaques and tangles. “Usually when a patient sees a doctor for suspected symptoms of dementia, the disease is already present,” Dr. Praticò added. “We want to know whether olive oil added at a later time point in the diet can stop or reverse the disease.”

Temple University

To receive daily emails from Breaking Christian News to your inbox CLICK HERE

PRAYER ALERT: US F-15 Fighter Jet Downed in SW Iran, 1 Pilot Rescued and Safe; Search Continues for Second One

Dutch Sheets: Good Friday Message & Communion

'I Began to Pray': Pastor Talks Down Crazed Man Who Points Gun Directly at Him, Leads 10 to Christ

Trump HHS Renews Planned Parenthood Grants for 'Final Year' Due to Legalities, But 'Funds CANNOT Be Used for Abortions'

WATCH: Families at the Center of Washington State Transgender Sports Debate Stand Firm for Truth

Levin: Ruling Against Birthright Citizenship Should Be a 'Slam-Dunk' for Supreme Court [Video]

Colorado Appeals Court Reverses Tina Peters' Sentencing, Could This Lead to Her Freedom?

March Job Growth Triples Expectations, Unemployment Rate Dips

Artemis II Mission Pilot: 'We Need Jesus; Whether Here on Earth or Orbiting the Moon'

Democrat Lawmaker Steps Down, Says Faith No Longer Aligns with Left's Agenda

Trump Administration Charges 9 in Massive Massachusetts Fraud Scheme

ICE Finally Detains Notorious Hamas Fundraiser Salah Sarsour; Decades of Terror Ties Exposed as AMP Leader Faces Deportation

Johnson, Thune Hatch Plan to Fund DHS and Launch a Second Reconciliation Push to End the Dem's Shutdown

Pentagon Briefed Trump on Plan to Seize Uranium from Hands of Iranian Terrorist Regime

President Trump Reassures Americans: Iran Operation Won't Be a Forever War

Pam Bondi OUT as Attorney General

Countdown for Historic Space Mission Artemis II Begins

Federal Judge Orders Trump Administration to Halt Construction on Privately Funded White House Ballroom; Trump Responds

Trump Rolls Out a Plan to Back Farmers amid Rising Costs, Pledging 'Golden Age'

Trump's Election Executive Order is Causing a Meltdown among Liberals