To receive daily emails from Breaking Christian News to your inbox CLICK HERE

"Our next step is to find out if this [a functional 'cure'] is a highly unusual response to very early antiretroviral therapy or something we can actually replicate in other high-risk newborns." ?Dr. Deborah Persaud

A team of researchers from Johns Hopkins Children's Center, the University of Mississippi Medical Center and the University of Massachusetts Medical School describe the first case of a so-called "functional cure" in an HIV-infected infant. The finding, the investigators say, may help pave the way to eliminating HIV infection in children.

A report on the case was presented at a press conference on Sunday, March 3, at the 20th Conference on Retroviruses and Opportunistic Infections (CROI) in Atlanta. Johns Hopkins Children's Center virologist Deborah Persaud, M.D., lead author on the report, and University of Massachusetts Medical School immunologist and professor Katherine Luzuriaga, M.D., headed a team of laboratory investigators. Pediatric HIV specialist Hannah Gay, M.D., associate professor of pediatrics at the University of Mississippi Medical Center provided treatment to the baby. (Photo: Dr. Katherine Luzuriaga)

The infant described in the report underwent remission of HIV infection after receiving antiretroviral therapy (ART) within 30 hours of birth. The investigators say the prompt administration of antiviral treatment likely led to this infant's cure by halting the formation of hard-to-treat viral reservoirs?dormant cells responsible for reigniting the infection in most HIV patients within weeks of stopping therapy.

"Prompt antiviral therapy in newborns that begins within days of exposure may help infants clear the virus and achieve long-term remission without lifelong treatment by preventing such viral hideouts from forming in the first place," Persaud says.

The researchers say they believe this is precisely what happened in the child described in the report. That infant is now deemed "functionally cured," a condition that occurs when a patient achieves and maintains long-term viral remission without lifelong treatment and standard clinical tests fail to detect HIV replication in the blood.

In contrast to a sterilizing cure?a complete eradication of all viral traces from the body?a functional cure occurs when viral presence is so minimal, it remains undetectable by standard clinical tests, yet discernible by ultrasensitive methods.

The child described in the current report was born to an HIV-infected mother and received combination antiretroviral treatment beginning 30 hours after birth. A series of tests showed progressively diminishing viral presence in the infant's blood, until it reached undetectable levels 29 days after birth. The infant remained on antivirals until 18 months of age, at which point the child was lost to follow-up for a while and, the researchers say, stopped treatment. Ten months after discontinuation of treatment, the child underwent repeated standard blood tests, none of which detected HIV presence in the blood. Test for HIV-specific antibodies?the standard clinical indicator of HIV infection?also remained negative throughout. (Photo: ITV News)

Currently, high-risk newborns?those born to mothers with poorly controlled infections or whose mothers' HIV status is discovered around the time of delivery?receive a combination of antivirals at prophylactic doses to prevent infection for six weeks and start therapeutic doses if and once infection is diagnosed. But this particular case, the investigators say, may change the current practice because it highlights the curative potential of very early ART.

Specialists say natural viral suppression without treatment is an exceedingly rare phenomenon observed in less than half a percent of HIV-infected adults, known as "elite controllers," whose immune systems are able to rein in viral replication and keep the virus at clinically undetectable levels. HIV experts have long sought a way to help all HIV patients achieve elite-controller status. The new case, the researchers say, may be that long-sought game-changer because it suggests prompt ART in newborns can do just that.

Read more at the link provided.

To receive daily emails from Breaking Christian News to your inbox CLICK HERE

Americans Split On Pastors Using AI, Skeptical It Can Help With Understanding the Bible

Daughters of the American Revolution to Vote on Definition of 'Woman' amid Criticism of Transgender Policy

FYI: These 568 Companies Are Paying to Trans Kids. A Nationwide Campaign Demands They Stop

'They Paid Me to Vote': Homeless Residents Make Explosive Claims after Spencer Pratt's Loss [Video]

America Becomes India's Top Gas Supplier amid Strait of Hormuz Conflict

Netanyahu: 'Iran Will Not Have Nuclear Weapons'

'Fauci, Biden Admin Lied to American People': DNI Gabbard Reveals Evidence of US Taxpayer-Funded Global Biolab Program

Human Trafficking Update: Feds Identify 15,500 Sponsors of Multiple Unaccompanied Kids

Ainsley Earhardt Celebrates America; Reveals Supernatural Experience That Strengthened Her Faith [Video]

Melania Trump Launches First-of-Its-Kind Foster Youth Accounts to Give Children Asset Ownership

Changing Tide: Record-low 38% of Americans Support 'Gender Transitions' - Gallup Poll

4 States Offering Pride Month Alternatives That Celebrate Family

PRO-LIFE WIN: Trump Admin Moves to Remedy Downfall of IVF

Karmelo Anthony Claims He's 'Penniless,' Can't Afford Lawyer for Appeal, Despite Pocketing $625,000, after Murder Conviction

Trump Says US Snuck 22 Oil Ships Past Iran in Covert Op, US Strikes Regime 2 Nights in a Row

Memphis Safe Task Force Surpasses 10,000 Arrests, Locates 154 Missing Children and Removes over 1,700 Firearms from City Streets

President Trump Signs $70 Billion Border Security, ICE Funding Bill that Includes Funding to Combat Child Trafficking

Report: Parents Remain Essential to Instilling Authentic Faith in Next Generation

Who Is Counseling Our Children?

Supreme Court Vacates Biden-Era Decision Outlawing Gas Stoves, Water Heaters

Steve Shultz, Managing Editor
Founder and Owner

Aimee Herd, Editor