To receive daily emails from Breaking Christian News to your inbox CLICK HERE
Apple Ingredient Keeps Muscles From Wasting with Illness and AgingThe healing property is in the peel. (Iowa City, IA) - In search of a way to prevent the muscle wasting that comes with illness and aging, researchers have landed a natural compound that might just do the trick. The findings reported in the June issue of Cell Metabolism, a Cell Press publication, identify a component of apple peels as a promising new drug candidate for the widespread and debilitating condition that affects nearly everyone at one time or another. "Muscle wasting is a frequent companion of illness and aging," said Christopher Adams of The University of Iowa, Iowa City. "It prolongs hospitalization, delays recoveries and in some cases prevents people from going back home. It isn't well understood and there is no medicine for it." Motivated by the desire to change that, Adams' team first looked at what happens to gene activity in muscles under conditions that promote weakening. Those studies turned up 63 genes that change in response to fasting in both people and mice and another 29 that shift their expression in the muscles of both people who are fasting and those with spinal cord injury. Comparison of those gene expression signatures to the signatures of cells treated with more than 1300 bioactive small molecules led them to ursolic acid as a compound with effects that might counteract those of atrophy. "Ursolic acid is an interesting natural compound," Adams said. "It's part of a normal diet as a component of apple peels. They always say that an apple a day keeps the doctor away..." The researchers next gave ursolic acid to fasted mice. Those experiments showed that ursolic acid could protect against muscle weakening as predicted. When ursolic acid was added to the food of normal mice for a period of weeks, their muscles grew. Those effects were traced back to enhanced insulin signaling in muscle and to corrections in the gene signatures linked to atrophy. Animals given ursolic acid also became leaner and had lower blood levels of glucose, cholesterol and triglycerides. The findings therefore suggest that ursolic acid may be responsible for some of the overall benefits of healthy eating. "We know if you eat a balanced diet like mom told us to eat you get this material," Adams said. "People who eat junk food don't get this." It is not yet clear whether the findings in mice will translate to human patients, Adams says, but his goal now is to "figure out if this can help people." If so, they don't yet know whether ursolic acid at levels that might be consumed as part of a normal diet might or might not be enough.
To receive daily emails from Breaking Christian News to your inbox CLICK HERE Other Recent Articles from Breaking Christian News Tens of Thousands Attend Jerusalem Annual Passover Priestly Blessing, Focus on Hostages, Families Pro-Life Democrat Runs 'Graphic' Abortion Ad during the 'Today' Show Outrage Follows Biden's Abortion Blessing at a Recent Rally Biden's EPA Rolls Out Regulations Aimed at Killing the American Coal Industry 8 GOP States (and Counting) Ban Biden's DOJ from 'Intimidating' Voters at 2024 Polls West Virginia Student Helps Pass Bill to Teach Intelligent Design: 'This Is a God-Fearing State' Free Speech Resolution Allows Satanic Temple 'Invocation' Sparking Chaos at a Michigan Board Meeting Paris Olympics Will Feature a 'Pride House' to 'Celebrate' Homosexual and Gender-Confused Athletes Video Captures Drag Queen Indoctrinating Kids, Getting Them to Chant... 'Free Palestine' Who's Funding the Anti-Israel, Pro-Palestine Protests? DEVELOPING: Harvey Weinstein Rape Conviction Overturned By New York Appellate Court Supreme Court Puts Final Nail in Coffin of Effort to Block Trump from Ballot in Arizona Courageous: Worship Leader Sean Feucht Prepares to Confront Anti-Israel Evil, Darkness, and Horror Search the Articles Archives |
All articles on this site and emails from BCN are copyrighted property of Breaking Christian News. Permission is given to link to, or share a BCN story if proper attribution is given to both the original writer and summarizer of the story. Breaking Christian News 2005-2019. All Rights Reserved.
Breaking Christian News is a division of Elijah List Publications, Inc. All Rights Reserved
Disclaimer: Articles and links, as well as the source articles linked to; do not necessarily reflect the opinion of Breaking Christian News.
Home | Store | Subscribe | Facebook | Article Archive |