To receive daily emails from Breaking Christian News to your inbox CLICK HERE

Elisabeth Lyons : Jan 10, 2011  Cell Press

In studies, betulin decreased lipids in liver and fat to a greater extent than lovastatin did. Betulin also improved insulin resistance through its effects on fatty acid and triglyceride synthesis.

An ingredient found in abundance in birch bark appears to have an array of metabolic benefits, according to new studies in animals that are reported in the January issue of Cell Metabolism, a Cell Press publication. In mice, the compound known as betulin lowered cholesterol, helped prevent diet-induced obesity, and improved insulin sensitivity. Betulin-treated mice were also more resistant to developing atherosclerotic plaques in their arteries.
Betulin works by targeting so-called sterol regulatory element-binding proteins (SREBPs), transcription factors that are known to be important for activating the expression of genes involved in the biosynthesis of cholesterol, fatty acids, and triglycerides.

"Our study shows that the SREBP pathway is a good target for several metabolic diseases," said Bao-Liang Song of the Shanghai Institutes for Biological Sciences. "We also identify a leading compound." (Photo: Wikipedia)

In the new study, Song and his colleagues went in search of a compound that might act directly on SREBP. That chemical screen turned up betulin as a top contender. They then confirmed in cells that betulin lowered the activity of genes that are normally switched "on" by SREBP. It also lowered lipid levels within cells.

Song's team then treated mice on a high-fat, Western diet with betulin, the cholesterol-lowering statin known as lovastatin, or a placebo (saline) for 6 weeks. Compared to placebo, both drugs led the mice to gain less weight on the high-fat diet, though by different means. Betulin caused the animals to burn more calories while lovastatin appeared to reduce the amount of lipid taken up from the diet.

Further investigations showed that betulin also lowered lipid levels in blood, liver, and fat tissue. Betulin also made the animals more sensitive to insulin. Mice with a mutation that makes them prone to develop atherosclerosis showed fewer plaques when treated with either lovastatin or betulin.

"Betulin has several major metabolic effects," Song said.

The researchers say that their findings suggest that betulin may have similar or even better effects than lovastatin, a member of the most widely prescribed drug class for treating high cholesterol. For instance, in their studies betulin decreased lipids in liver and fat to a greater extent than lovastatin did. Betulin also improved insulin resistance through its effects on fatty acid and triglyceride synthesis.

Song notes that betulin is a readily available compound and is already in use as a precursor in the manufacture of other drugs.

Although betulin appears to have very low toxicity, he says future studies will need to further investigate the safety of betulin and its metabolic effects. Researchers will also explore the possibility that a derivative of betulin might have even greater potency. "That may be the path forward to move this clinically," Song said.

To receive daily emails from Breaking Christian News to your inbox CLICK HERE

Thanksgiving: The Quintessential American Holiday

Mamdani Could Threaten Future of Pregnancy Care Centers, Pro-Life CEO Warns

Texas: Strongman Games World Championship Disqualifies Winner, Strips Him of 'Women's Open Title' Victory after Discovering He's Biologically Male

Parents Sue School District after 11-Year-Old Girl Was Forced to Share Bed With 'Transgender' Boy

Department of War Says Senator Kelly Faces Possible Court-Martial for 'Seditious' Video

Chicago Train Burning Shows How Too Much Leniency to the Guilty Is Cruelty to the Innocent

FDA's Makary: Fauci Orchestrated 'Massive Cover-Up' of COVID Origin

2 National Guard Members Shot in 'Targeted Attack' in Washington DC; Suspect Is in Custody

Remembering 'A Charlie Brown Thanksgiving'

Exposed: Soros Family Has Been Working With the US State Department for 50 Years, Wikileaks Shows

Bishops Vote to Prohibit Trans Surgeries and Hormone Treatment in Catholic Hospitals

Do No Harm Survey Shows Rank-and-File Doctors Oppose DEI in Healthcare

Federal Report Exposes Sacramento's Failure: AAP, AMA, WPATH Lied and Lawmakers Let Children Pay the Price

FBI's Patel and Bongino Share Details of Op that Stopped Huge Halloween Islamic Terror Plot: 'A Lot of People Would've Died'

President Trump Designates Muslim Brotherhood as a Foreign Terrorist Organization

Same Old Tricks: Big Tech News 'Aggregators' Suppress Dem Scandals in Lead-Up to Elections

Maryland School Board Resists State’s Attempt to Override Removal of Explicit LGBT Book

All Living Israeli Hostages Now Home, Embraced by Medical Staff and Loving Communities, Yet Facing Long Recovery

Chicago public schools blow millions on travel expenses while students can't read at grade level

'That doesn't exist': Doge reportedly quietly disbanded ahead of schedule

Steve Shultz, Managing Editor
Founder and Owner

Aimee Herd, Editor