To receive daily emails from Breaking Christian News to your inbox CLICK HERE

"What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grape seed extract fits into this category."

An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to researchers from the University of Kentucky. They found that within 24 hours, 76 percent of leukemia cells had died after being exposed to the extract.

The investigators, who report their findings in the January 1, 2009, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, also teased apart the cell signaling pathway associated with use of grape seed extract that led to cell death, or apoptosis. They found that the extract activates JNK, a protein that regulates the apoptotic pathway.

While grape seed extract has shown activity in a number of laboratory cancer cell lines, including skin, breast, colon, lung, stomach and prostate cancers, no one had tested the extract in hematological cancers nor had the precise mechanism for activity been revealed.

"These results could have implications for the incorporation of agents such as grape seed extract into prevention or treatment of hematological malignancies and possibly other cancers," said the study's lead author, Xianglin Shi, Ph.D., professor in the Graduate Center for Toxicology at the University of Kentucky.

"What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grape seed extract fits into this category," he said.

Shi adds, however, that the research is not far enough along to suggest that people should eat grapes, grape seeds, or grape skin in excess to stave off cancer. "This is very promising research, but it is too early to say this is chemo-protective."

Hematological cancers—leukemia, lymphoma and myeloma—accounted for an estimated 118,310 new cancer cases and almost 54,000 deaths in 2006, ranking these cancers as the fourth leading cause of cancer incidence and death in the U.S.

Given that epidemiological evidence shows that eating vegetables and fruits helps prevent cancer development, Shi and his colleagues have been studying chemicals known as proanthocyanidins in fruits that contribute to this effect. Shi has found that apple peel extract contains these flavonoids, which have antioxidant activity, and which cause apoptosis in several cancer cell lines but not in normal cells. Based on those studies, and findings from other researchers that grape seed extract reduces breast tumors in rats and skin tumors in mice, they looked at the effect of the compound in leukemia cells.

Using a commercially available grape seed extract, Shi exposed leukemia cells to the extract in different doses and found the marked effect in causing apoptosis in these cells at one of the higher doses.

They also discovered that the extract does not affect normal cells, although they don't know why.

"This is a natural compound that appears to have relatively important properties," Shi said.

To receive daily emails from Breaking Christian News to your inbox CLICK HERE

Americans Split On Pastors Using AI, Skeptical It Can Help With Understanding the Bible

Daughters of the American Revolution to Vote on Definition of 'Woman' amid Criticism of Transgender Policy

FYI: These 568 Companies Are Paying to Trans Kids. A Nationwide Campaign Demands They Stop

'They Paid Me to Vote': Homeless Residents Make Explosive Claims after Spencer Pratt's Loss [Video]

America Becomes India's Top Gas Supplier amid Strait of Hormuz Conflict

Netanyahu: 'Iran Will Not Have Nuclear Weapons'

'Fauci, Biden Admin Lied to American People': DNI Gabbard Reveals Evidence of US Taxpayer-Funded Global Biolab Program

Human Trafficking Update: Feds Identify 15,500 Sponsors of Multiple Unaccompanied Kids

Ainsley Earhardt Celebrates America; Reveals Supernatural Experience That Strengthened Her Faith [Video]

Melania Trump Launches First-of-Its-Kind Foster Youth Accounts to Give Children Asset Ownership

Changing Tide: Record-low 38% of Americans Support 'Gender Transitions' - Gallup Poll

4 States Offering Pride Month Alternatives That Celebrate Family

PRO-LIFE WIN: Trump Admin Moves to Remedy Downfall of IVF

Karmelo Anthony Claims He's 'Penniless,' Can't Afford Lawyer for Appeal, Despite Pocketing $625,000, after Murder Conviction

Trump Says US Snuck 22 Oil Ships Past Iran in Covert Op, US Strikes Regime 2 Nights in a Row

Memphis Safe Task Force Surpasses 10,000 Arrests, Locates 154 Missing Children and Removes over 1,700 Firearms from City Streets

President Trump Signs $70 Billion Border Security, ICE Funding Bill that Includes Funding to Combat Child Trafficking

Report: Parents Remain Essential to Instilling Authentic Faith in Next Generation

Who Is Counseling Our Children?

Supreme Court Vacates Biden-Era Decision Outlawing Gas Stoves, Water Heaters

Steve Shultz, Managing Editor
Founder and Owner

Aimee Herd, Editor