|
To receive daily emails from Breaking Christian News to your inbox CLICK HERE
The End of Heart Disease? Groundbreaking Experiment Stops Cholesterol BuildupUsing mice and rabbits, Johns Hopkins scientists were able to successfully prevent the development of arteriosclerosis by halting a single molecule responsible for purging cholesterol in blood vessels.
In a series of experiments, described April 7 in the journal Circulation, the Johns Hopkins team says it identified and halted the action of a single molecular culprit responsible for a range of biological glitches that affect the body's ability to properly use, transport and purge itself of cholesterol — the fatty substance that accumulates inside vessels and fuels heart disease. The offender, the researchers say, is a fat-and-sugar molecule called glycosphingolipid, or GSL, which resides in the membranes of all cells, and is mostly known for regulating cell growth. Results of the experiments, the scientists say, reveal that this very same molecule also regulates the way the body handles cholesterol.
"Current cholesterol-lowering medications tackle the problem on a single front — either by blocking cholesterol synthesis or by preventing the body from absorbing too much of it," says lead investigator Subroto Chatterjee, Ph.D., a cardio-metabolic expert at the Johns Hopkins Children's Center. "But atherosclerosis is a multi-factorial problem that requires hitting the abnormal cholesterol cycle at many points. By inhibiting the synthesis of GSL, we believe we have achieved exactly that." Specifically, the experiments showed that treatment with D-PDMP led to: • a drop in the animals' levels of so-called bad cholesterol or low-density lipoprotein, LDL; • a drop in oxidized LDL, a particularly virulent form of fat that forms when LDL encounters free radicals. Oxidized LDL easily sticks to the walls of blood vessels, where it ignites inflammation, damaging the vessel walls and promoting the growth of fatty plaque; • a surge in good cholesterol or high-density lipoprotein, HDL, known to counteract the effects of LDL by mopping it up; and • a significant drop in triglycerides, another type of plaque-building fat. The treatment also prevented fatty plaque and calcium deposits from building up inside the animals' vessels. These effects were observed in animals on a daily D-PDMP treatment even though they ate a diet made up of 20 percent triglycerides—the human equivalent of eating a greasy burger for breakfast, lunch and dinner. In addition, the researchers say, D-PDMP appears to precision-target the worst byproducts of aberrant cell growth signaling, such as oxidized LDL and the activity of certain chemicals that fuel vessel inflammation, without altering cell growth itself. Read more by Clicking Here. 
To receive daily emails from Breaking Christian News to your inbox CLICK HERE
Other Recent Articles from Breaking Christian News Tens of Thousands Attend Jerusalem Annual Passover Priestly Blessing, Focus on Hostages, Families Pro-Life Democrat Runs 'Graphic' Abortion Ad during the 'Today' Show Outrage Follows Biden's Abortion Blessing at a Recent Rally Biden's EPA Rolls Out Regulations Aimed at Killing the American Coal Industry 8 GOP States (and Counting) Ban Biden's DOJ from 'Intimidating' Voters at 2024 Polls West Virginia Student Helps Pass Bill to Teach Intelligent Design: 'This Is a God-Fearing State' Free Speech Resolution Allows Satanic Temple 'Invocation' Sparking Chaos at a Michigan Board Meeting Paris Olympics Will Feature a 'Pride House' to 'Celebrate' Homosexual and Gender-Confused Athletes Video Captures Drag Queen Indoctrinating Kids, Getting Them to Chant... 'Free Palestine' Who's Funding the Anti-Israel, Pro-Palestine Protests? DEVELOPING: Harvey Weinstein Rape Conviction Overturned By New York Appellate Court Supreme Court Puts Final Nail in Coffin of Effort to Block Trump from Ballot in Arizona Courageous: Worship Leader Sean Feucht Prepares to Confront Anti-Israel Evil, Darkness, and Horror |
    
  |
(Baltimore, MD)—Working with mice and rabbits, Johns Hopkins scientists have found a way to block abnormal cholesterol production, transport and breakdown, successfully preventing the development of atherosclerosis, the main cause of heart attacks and strokes and the number-one cause of death among humans. The condition develops when fat builds inside blood vessels over time and renders them stiff, narrowed and hardened, greatly reducing their ability to feed oxygen-rich blood to the heart muscle and the brain. (Photo via humanlyexhausted.com) 
The Johns Hopkins team used an existing man-made compound called D-PDMP to block the synthesis of the GSL molecule, and by doing so, prevented the development of heart disease in mice and rabbits fed a high-fat, cholesterol-laden diet. The findings reveal that D-PDMP appears to work by interfering with a constellation of genetic pathways that regulate fat metabolism on multiple fronts—from the way cells derive and absorb cholesterol from food, to the way cholesterol is transported to tissues and organs and is then broken down by the liver and excreted from the body. (Photo via DrLavanga.com) 
All articles on this site and emails from BCN are copyrighted property of Breaking Christian News. Permission is given to link to, or share a BCN story if proper attribution is given to both the original writer and summarizer of the story. Breaking Christian News 2005-2019. All Rights Reserved.
Breaking Christian News is a division of Elijah List Publications, Inc. All Rights Reserved
Disclaimer: Articles and links, as well as the source articles linked to; do not necessarily reflect the opinion of Breaking Christian News.
| Home | Store | Subscribe | Facebook | Article Archive |