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Health: Big News in Drive to Find Alzheimer's Cure

Dr. Don Colbert : Mar 19, 2019  Divine Health

Scientists continue to make great advances in brain health and treatment. There is a lot of hope for cures to degenerative brain diseases in the near future. In the meantime, practice habits that promote brain health each day.

airlift[DrColbert.com] Researchers from Yale just created and tested a drinkable cocktail of "designer molecules" that may stop the first pathological step of Alzheimer's disease. (Image: Pixabay)

It may even restore memory to cells already affected.

This is big news for brain health.

A few days ago in the journal Cell Reports, investigators reported that molecules were identified that could interfere with the progression of healthy brain prion protein cells, to those with Alzheimer's or other brain degenerative disease (1).

PRION PROTEINS AND ALZHEIMER'S DISEASE

Prion proteins are protein carbohydrate combinations found on brain neurons and spinal cord cells.

When they are healthy, they set on the outside of the neurons without causing harm. However, when they interact with amyloid beta peptides, they form a folded structure which has dire consequences (2).

Amyloid beta peptides portions of a larger protein that has broken off and become diseased and destructive.

Once infected and folded, prion proteins resist healing and recycling like healthy proteins. Instead, they proliferate and cause a devastating cascade of degenerative events (3). These include:

The accumulation of brain plaques

An immune system response that is destructive to the brain

Damage of brain synapses

Together, these events lead to degeneration of brain function and structure, contributing to the formation of lethal sponge-like holes in the brain.

THE DESIGNER MOLECULE COCKTAIL STUDY

Knowing this, Yale researchers set out to find a molecule or combination of molecules that could halt this devastating interaction or prion protein with amyloid beta and progression that follows.

After studying tens of thousands of molecules they found that an old antibiotic that initially proved promising.

However, it was only effective after it decomposed into a polymer.

With this data in hand, they searched further and found small polymers that remained active and effective for use. What's more, these polymers could also cross the blood-brain barrier... Subscribe for free to Breaking Christian News here

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