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Surprise Scientific Discovery: Human Individuality Not in Our Genes, but in Whatever "Controls" Our Genes

Teresa Neumann : Mar 24, 2010 : Stanford University Medical Center - Science Daily

"The discovery suggests that researchers focusing exclusively on genes to learn what makes people different from one another have been looking in the wrong place...The bulk of the differences among individuals are not found in the genes themselves, but in regions we know relatively little about."

REPORTER'S NOTE: Hmm. I wonder what "it" is that controls our genes? -Teresa Neumann, BCN.

"For You formed my inward parts; You wove me in my mother's womb." -Psalm 139:13

Genes graphicA report in Science Daily says "the key to human individuality may lie not in our genes, but in the sequences that surround and control them, according to new research by scientists at the Stanford University School of Medicine and Yale University. The interaction of those sequences with a class of key proteins, called transcription factors, can vary significantly between two people and are likely to affect our appearance, our development and even our predisposition to certain diseases, the study found." (Graphic: ScienceDaily.com)

The discovery, notes the report, suggests that researchers focusing exclusively on genes to learn what makes people different from one another have been looking in the wrong place.

"We are rapidly entering a time when nearly anyone can have his or her genome sequenced," said Michael Snyder, PhD, professor and chair of genetics at Stanford. "However, the bulk of the differences among individuals are not found in the genes themselves, but in regions we know relatively little about. Now we see that these differences profoundly impact protein binding and gene expression."

According to the report, "Genes, which carry the specific instructions necessary to make proteins do the work of the cell, vary by only about 0.025 percent across all humans. Scientists have spent decades trying to understand how these tiny differences affect who we are and what we become. In contrast, non-coding regions of the genome, which account for approximately 98 percent of our DNA, vary in their sequence by about 1 to 4 percent. But until recently, scientists had little, if any, idea what these regions do and how they contribute to the "special sauce" that makes me, me, and you, you."

Read the entire report by clicking on the link below.

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