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"Remarkable" Results With New Breast Cancer Drug After Breakthrough Trial Gives Women a "Second Chance at Life""I am now in remission, and everyday I'm thankful to God that I'm alive and able to see my great-grandchildren and spend time with them." -Gloria Zollar, four years after being diagnosed with advanced breast cancer which had spread to her bones (Los Angeles, CA)—In a groundbreaking study that offers new hope for women with advanced breast cancer, researchers from UCLA's Jonsson Comprehensive Cancer Center have published final clinical trial results that showed the amount of time patients were on treatment without their cancer worsening (called progression-free survival) was effectively doubled in women with advanced breast cancer who took the experimental drug palbociclib.
An investigational drug discovered and being developed by Pfizer Inc., palbociclib targets a key family of proteins (CDK4/6) responsible for cell growth by preventing them from dividing. Results of the multi-year phase 2 study showed a significant increase in PFS for patients with advanced breast cancer that was estrogen receptor positive (ER+), HER2-negative (HER2-), who were given a combination of the standard anti-estrogen treatment, letrozole, and palbociclib compared to letrozole alone.
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