Scientists from the French National Institute for Agricultural Research (INRA) and the French National Institute of Health and Medical Research (INSERM), along with Canadian and Swiss colleagues, have shown that Elafin, a protein with anti-inflammatory properties, is less abundant in patients with celiac disease than in healthy people. They identified that Elafin is capable of preventing the destruction of the gut barrier during inflammation, and that Elafin is able to interact with enzymes responsible for the abnormal breakdown of gluten: transglutaminase-2. Consequently, Elafin reduces gluten toxicity.

These observations led the scientists to propose a way to deliver the missing Elafin in celiac patients with help of a harmless bacterium that is often present in food: a lactic bacterium strain (Lactococcus lactis), that scientists transformed in order to express Elafin. The use of this strain, developed by the same teams from INRA and INSERM, enables a targeted and local production of Elafin, and represents a recent and innovative strategy. The first pre-clinical results pave the way to new therapies for Inflammatory Bowel Disease or IBD (no curative treatment exist).

In the present study, the scientists have administered this bacterium to gluten intolerant mice. They showed that the Elafin delivered by the probiotic decreases significantly the inflammatory reaction.

This strategy, patented by INRA in May 2013, opens promising prospects to treat celiac disease and gluten intolerance in general. The next step will consist in defining the mechanisms underlying the positive effects of Elafin in celiac disease, and in the identification of bacteria that naturally produce proteins with anti-inflammatory properties similar to Elafin.

To receive daily emails from Breaking Christian News to your inbox CLICK HERE

Hundreds Accept Jesus Christ in Poland at Franklin Graham Rally

Grammy-Winning Christian Artist Mandisa Has Died: Report

How You Can Send Letters of Encouragement to Jailed Pro-Life Heroes

'Americans Cannot Allow the Biden Administration to Sign Away Their Birthright': Congressmen Warn of WHO Pandemic Agreement

Illegal Immigrants Being Moved into Soldiers' Home Where Veterans Must Pay to Stay

House Democrats Vow to Codify 'Rights' to Trans Surgeries, Hormones, Puberty Blockers

18-Year-Old Female Trans Student Charged for Planning Two Maryland School Shootings, Manifesto Said She Wanted to Be 'Famous'

Israel Strikes Deep Inside Iran, Nuclear Facilities NOT Hit

An Important Message from Japan to the world about the WHO, Japan and the Next So-called 'Vaccine'

Rand Paul: Brave Marine Revealed that 15 US Agencies Knew COVID-19 Was Created in Lab in 2018; But They Kept It Secret from American Public (VIDEO)

Confirmed: Researchers Reveal COVID mRNA Vaccines Contain Component that Suppresses Immune Response and Stimulates Cancer Growth

Farmers, Truckers Warn California Emissions Mandates Will Cause 'Catastrophic' Supply Chain Crisis

Fed Court Overturns State Law Protecting Women's Sports from 'Transgender' Athletes

Furry Infestation: Middle School Students Walk Out in Protest after School Leaders Allow 'Furries' to Terrorize Them (VIDEO)

Biden's Education Secretary Vows to Shut Down the Largest Christian University in the US

US to Back Rafah Op in Exchange for Israel Dropping Major Iran Strike; Report

Schumer Succeeds in Killing Off Mayorkas Impeachment Trial before It Can Even Begin

California Town Tears Down Beloved Hillside Cross

Danielle Smith Again Defends Alberta's Coming Ban on Transgender Mutilation of Children

Detransitioners: We Were Pushed to Transition as Teens, Now We're 'Vindicated' By Study Showing Kids Grow Out of It